Tolvaptan
Jynarque (tolvaptan) is a brand-name medication that belongs to a class of drugs called vasopressin V2 receptor antagonists. It is primarily used to slow kidney cyst growth and preserve kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD). The medication works by blocking the action of vasopressin, a hormone that promotes fluid retention in the kidneys.
Jynarque is a prescription medication used to treat autosomal dominant polycystic kidney disease (ADPKD) by blocking vasopressin and slowing kidney cyst growth.
Key facts at a glance
- RxNorm
- 2044350
- Generic
- Jynarque
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Jynarque is FDA-approved to slow kidney cyst growth and decline in kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD). It is also available in a lower-dose formulation (Samsca) for treating hyponatremia (low blood sodium levels).
Jynarque blocks vasopressin V2 receptors in the kidneys, which reduces the reabsorption of water and increases urine output. By inhibiting vasopressin's effects on kidney cells, it helps slow the growth of cysts that characterize ADPKD.
Jynarque can cause serious liver injury and requires regular liver function monitoring. Patients should not use it if they cannot make urine or have severe dehydration. Common side effects include thirst, dry mouth, and frequent urination. The medication should not be used during pregnancy due to potential harm to the fetus. Patients should have access to water and be able to drink freely while taking this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy