Prothrombin Complex Concentrate
Kcentra is a prothrombin complex concentrate (PCC) used for the urgent reversal of warfarin anticoagulation in patients experiencing acute major bleeding. It contains vitamin K-dependent clotting factors (II, VII, IX, and X) and works faster than fresh frozen plasma to restore normal clotting. It is typically administered in emergency settings such as intracranial hemorrhage or severe trauma.
Kcentra is an IV medication used in emergencies to quickly reverse warfarin effects in patients with major bleeding.
Key facts at a glance
- RxNorm
- 1484959
- Generic
- Kcentra
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Acute major bleeding in warfarin-treated patients, including intracranial hemorrhage, serious trauma, and emergency surgery requiring urgent anticoagulation reversal.
Replaces vitamin K-dependent clotting factors (II, VII, IX, X) that are depleted by warfarin, rapidly restoring the body's ability to form clots.
Must be given with intravenous vitamin K for sustained effect. Requires INR monitoring before and after administration. Carries risk of thromboembolic events and hypersensitivity reactions. Administered only by healthcare professionals in monitored settings.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy