Levoleucovorin
Khapzory is a brand-name medication containing levoleucovorin, a folate analog used as a rescue agent to reduce methotrexate toxicity and as a treatment for certain folate-deficiency anemias. It is typically administered in healthcare settings by healthcare professionals.
Khapzory is a folate analog rescue agent used to mitigate methotrexate toxicity and treat certain folate-deficiency anemias.
Key facts at a glance
- RxNorm
- 2106369
- Generic
- Khapzory
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Reduces toxic effects associated with high-dose methotrexate therapy in patients with osteosarcoma; also used for folate deficiency-related megaloblastic anemias when oral therapy is not feasible.
Levoleucovorin is a reduced form of folate that bypasses the dihydrofolate reductase enzyme inhibited by methotrexate, allowing normal DNA synthesis to resume in healthy cells.
Must be used with caution in patients with certain medical conditions. Should not be used for intrathecal administration. Treatment should be supervised by healthcare providers experienced in high-dose methotrexate therapy and management of toxicities.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy