Anakinra
Kineret (anakinra) is a biologic medication that blocks interleukin-1 (IL-1), a protein involved in inflammation. It is primarily used to treat moderate to severe rheumatoid arthritis in patients who have not responded adequately to other disease-modifying drugs, as well as certain rare inflammatory conditions known as cryopyrin-associated periodic syndromes (CAPS).
Kineret is an IL-1 inhibitor biologic injection used to treat rheumatoid arthritis and certain rare inflammatory conditions by reducing inflammation in the body.
Key facts at a glance
- RxNorm
- 352734
- Generic
- Kineret
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Kineret is FDA-approved for the treatment of moderate to severe rheumatoid arthritis in adults who have not responded to one or more disease-modifying antirheumatic drugs (DMARDs), and for cryopyrin-associated periodic syndromes (CAPS) including neonatal-onset multisystem inflammatory disease (NOMID). It may also be used for systemic juvenile idiopathic arthritis (SJIA) and Adult-Onset Still's Disease (AOSD).
Kineret is a recombinant form of the human interleukin-1 receptor antagonist (IL-1Ra). It works by blocking the activity of interleukin-1 (IL-1), a pro-inflammatory cytokine that contributes to joint inflammation and damage in rheumatoid arthritis, as well as the systemic inflammation seen in CAPS and Still's disease.
Kineret is administered as a daily subcutaneous injection. Common side effects include injection site reactions, headache, nausea, and increased risk of infections. Patients should be monitored for signs of infection during treatment. It may be used alone or in combination with other DMARDs. Live vaccines should be avoided while taking Kineret. Treatment should be discontinued if a serious infection develops.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy