n/a
Klisyri is a topical prescription medication used to treat actinic keratosis, a common precancerous skin condition caused by cumulative sun exposure. The ointment is applied directly to affected areas on the face or scalp. This treatment is typically considered when topical field therapy is appropriate for patients.
Klisyri is a topical ointment used to treat precancerous actinic keratosis lesions on the face or scalp.
Key facts at a glance
- RxNorm
- 2471096
- Generic
- Klisyri
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Klisyri is indicated for the topical treatment of actinic keratosis (AK) on the face or scalp. Actinic keratosis are rough, scaly patches caused by years of sun exposure and are considered precancerous lesions that may develop into squamous cell carcinoma if left untreated.
The active ingredient in Klisyri is tirbanibulin, a microtubule inhibitor. It works by binding to tubulin and inhibiting microtubule polymerization, which disrupts cellular structure and function, ultimately leading to cell death (apoptosis) of the abnormal keratinocytes in actinic keratosis lesions.
Klisyri is for external use only and should not be used near the eyes, mouth, or lips. Common side effects may include local skin reactions such as redness, flaking, crusting, and swelling at the application site. Patients should avoid washing or touching the treated area for approximately 8 hours after application. Sun exposure should be minimized during and after treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy