Mifepristone
Korlym is a glucocorticoid receptor antagonist used to control hyperglycemia in adults with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and for whom surgery has not been successful or is not an option. It works by blocking the effects of cortisol at the receptor level.
Korlym is a brand-name medication used to manage high blood sugar in adults with Cushing's syndrome when surgery is not an option.
Key facts at a glance
- RxNorm
- 1245263
- Generic
- Korlym
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Korlym is indicated for the control of hyperglycemia (high blood sugar) in adults with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance, and for whom surgery has not been successful or is not an option.
Korlym contains mifepristone, which acts as a competitive antagonist at the glucocorticoid receptor, blocking the effects of cortisol (a glucocorticoid hormone) that contributes to hyperglycemia in Cushing's syndrome.
Korlym is contraindicated in pregnancy due to its abortifacient properties. Common adverse effects include nausea, fatigue, headache, arthralgia, and vomiting. It may cause hypokalemia and requires regular monitoring. Patients should be under the care of a healthcare provider experienced with its use.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy