Difelikefalin
Korsuva is a prescription medication containing the active ingredient difelikefalin. It is specifically approved for the treatment of moderate-to-severe pruritus (itching) in adults with chronic kidney disease (CKD) who are undergoing hemodialysis. This medication is administered as an intravenous injection during hemodialysis sessions.
Korsuva is used to treat itching in adults with kidney disease who are on hemodialysis.
Key facts at a glance
- RxNorm
- 2569096
- Generic
- Korsuva
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Korsuva is indicated for the treatment of moderate-to-severe pruritus (itching) associated with chronic kidney disease (CKD) in adult patients undergoing hemodialysis. Uremic pruritus is a common and often debilitating symptom in patients with end-stage renal disease.
Korsuva is a kappa opioid receptor agonist. It works by activating kappa opioid receptors in the central nervous system, which helps reduce the sensation of itching. The exact pathways involved in uremic pruritus are complex, but this mechanism is believed to modulate the itch signaling.
Korsuva is administered intravenously at the end of hemodialysis sessions, typically three times per week. Common side effects may include diarrhea, dizziness, nausea, and gait disturbances. Patients should inform their healthcare provider of all medications and medical conditions before starting treatment. Safety in pregnancy and breastfeeding has not been established. Dosage may be adjusted based on individual patient response and tolerability.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy