Lemborexant
Lemborexant is a prescription medication used to treat adults with insomnia who struggle with falling asleep and/or staying asleep. It belongs to a class of drugs called dual orexin receptor antagonists (DORAs) that work by blocking natural brain chemicals that promote wakefulness. Taken orally at bedtime, it helps facilitate sleep onset and maintenance.
Lemborexant is a prescription sleep aid that works by blocking wake-promoting orexin receptors to help adults with insomnia fall asleep and stay asleep.
Key facts at a glance
- ATC
- N05CJ02
- RxNorm
- 2272403
- Generic
- Lemborexant
- Class
- atc-n05
- Brands
- Dayvigo
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lemborexant is indicated for the treatment of adult patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.
Lemborexant is a dual orexin receptor antagonist (DORA). It works by blocking orexin A and orexin B receptors in the brain. The orexin system plays a key role in promoting wakefulness, and by inhibiting these receptors, lemborexant helps reduce arousal and facilitate sleep.
May cause next-day drowsiness and impaired driving. Can cause complex sleep behaviors such as sleepwalking and sleep-driving. Should be taken at bedtime with at least 7 hours remaining before waking. Avoid use with alcohol. Not recommended in patients with narcolepsy. Use with caution in patients with depression or history of suicidal ideation.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy