Lenalidomide
Lenalidomide is an immunomodulatory drug used primarily to treat certain blood cancers, including multiple myeloma and myelodysplastic syndromes. It works by targeting the cereblon protein to modulate immune responses and inhibit tumor blood vessel formation.
An immunomodulatory cancer drug used for multiple myeloma and related blood disorders.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L04AX04
- RxNorm
- 342369
- Generic
- Lenalidomide
- Class
- atc-l04
- Brands
- Revlimid
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
FDA-approved for multiple myeloma (typically with dexamethasone), myelodysplastic syndromes with deletion 5q, and mantle cell lymphoma. Often used in patients who have received prior therapies.
Binds to cereblon, a component of an E3 ubiquitin ligase complex, leading to degradation of specific transcription factors. This produces immunomodulatory effects, reduces angiogenesis, and exerts direct antineoplastic activity against cancer cells.
Highly teratogenic—strict pregnancy prevention required with REMS program enrollment. Common side effects include cytopenias, blood clots, and fatigue. Requires regular blood monitoring and dose adjustments. Distribution is restricted under a risk management program.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy