Lenvatinib
Lenvatinib is a multi-targeted kinase inhibitor used to treat certain cancers by blocking enzymes involved in tumor growth and blood vessel formation. It is prescribed for differentiated thyroid cancer, advanced renal cell carcinoma, hepatocellular carcinoma, and advanced endometrial carcinoma.
Lenvatinib is a cancer treatment that inhibits kinases involved in angiogenesis and tumor growth.
Key facts at a glance
- ATC
- L01EX08
- RxNorm
- 1603296
- Generic
- Lenvatinib
- Class
- atc-l01
- Brands
- Lenvima
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lenvatinib is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer; advanced renal cell carcinoma in combination with everolimus; unresectable hepatocellular carcinoma; and advanced endometrial carcinoma that is not MSI-H or dMMR.
Lenvatinib inhibits the kinase activities of vascular endothelial growth factor receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4), as well as other kinases implicated in pathogenic angiogenesis, tumor growth, and cancer progression.
Lenvatinib carries warnings for serious adverse events including hypertension, cardiac failure, hemorrhage, arterial thromboembolism, hepatotoxicity, renal failure, gastrointestinal perforation, and QT prolongation. Regular monitoring of blood pressure, cardiac function, liver function, and thyroid function is essential during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy