Inclisiran
Leqvio (inclisiran) is a prescription injectable medication used to lower LDL (bad) cholesterol in adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who need additional cholesterol reduction. It is administered as a subcutaneous injection by a healthcare provider twice yearly and is used alongside a healthy diet and maximally tolerated statin therapy.
Leqvio is an injectable PCSK9-targeting therapy that lowers LDL cholesterol in certain adults with high cardiovascular risk.
Key facts at a glance
- RxNorm
- 2588265
- Generic
- Leqvio
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Leqvio is indicated for adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who require additional LDL-C lowering on top of diet and statin therapy.
Leqvio contains inclisiran, a small interfering RNA (siRNA) that targets and reduces production of PCSK9 protein in the liver, allowing more LDL receptors to remain active and remove LDL cholesterol from the bloodstream.
Leqvio is administered as a subcutaneous injection by a healthcare professional twice yearly (every 6 months). Common side effects may include injection site reactions. It should be used with diet and statin therapy and is not for use in patients with severe hepatic impairment or during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy