Levocetirizine
Levocetirizine is a second-generation antihistamine used to treat allergic conditions such as seasonal allergies (hay fever), perennial allergic rhinitis, and chronic idiopathic urticaria (hives). It works by blocking H1 histamine receptors, reducing allergy symptoms like sneezing, itching, runny nose, and watery eyes.
A non-sedating antihistamine used to relieve allergy symptoms including sneezing, itching, and runny nose.
Key facts at a glance
- ATC
- R06AE04
- RxNorm
- 856447
- Generic
- Levocetirizine
- Class
- atc-r06
- Brands
- Xyzal
- Availability
- otc
- Pregnancy
- C
- Lactation
- caution
- Half-life (h)
- 8
- Onset (min)
- 60
- Duration (h)
- 24
- Routes
- oral
- Forms
- tablet, oral solution
- Regions
- United States, European Union, Canada, Australia, India
- Monitoring
- drowsiness, dry mouth
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats seasonal allergic rhinitis (hay fever), perennial allergic rhinitis, and chronic idiopathic urticaria (hives). Effective for symptoms including sneezing, nasal itching, rhinorrhea, itchy eyes, and skin itching.
A selective H1 receptor antagonist that blocks histamine from binding to its receptors, preventing the allergic response. As the active enantiomer of cetirizine, it provides antihistamine activity with reduced sedation compared to first-generation antihistamines.
Typically taken once daily in the evening. May cause mild drowsiness in some individuals. Use with caution in patients with kidney impairment as dosing adjustment may be needed. Generally not recommended during pregnancy or breastfeeding without medical advice. Avoid operating heavy machinery until knowing how the medication affects you.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy