Levomefolate
Levomefolate is the active form of folate (vitamin B9) that plays a crucial role in DNA synthesis, amino acid metabolism, and cell division. It is used to treat folate deficiency and is particularly important for pregnant women to prevent neural tube defects in developing fetuses.
Levomefolate is the metabolically active form of folate used to treat deficiency and support pregnancy, brain health, and conditions requiring enhanced methyl-group metabolism.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- RxNorm
- 1592257
- Generic
- Levomefolate
- Class
- unclassified
- Brands
- Folixate
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Levomefolate is used to treat folate deficiency, support healthy pregnancy outcomes by preventing neural tube defects, manage conditions associated with impaired folate metabolism (such as MTHFR gene mutations), and as adjunctive therapy for certain psychiatric conditions including depression when standard treatments are inadequate.
Levomefolate bypasses the enzymatic conversion steps required by synthetic folic acid, directly entering the folate cycle to serve as a methyl donor in the conversion of homocysteine to methionine. This supports neurotransmitter synthesis, DNA methylation, and cellular repair processes.
Unlike folic acid, levomefolate does not mask vitamin B12 deficiency, making it safer for certain populations. It is generally well-tolerated but should be used under medical supervision, especially during pregnancy or when combining with other medications that affect folate metabolism.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy