Levonordefrin
Levonordefrin is a synthetic sympathomimetic amine with vasoconstrictive properties, primarily used as an adjunct to local anesthetics in dental procedures. It works by stimulating alpha-adrenergic receptors, causing local vasoconstriction to reduce blood flow and prolong anesthetic effect.
Levonordefrin is a vasoconstrictor used with local anesthetics in dental procedures to reduce bleeding and extend numbness.
Key facts at a glance
- RxNorm
- 132889
- Generic
- Levonordefrin
- Class
- unclassified
- Brands
- Carbocaine with NeoCobefrin
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used primarily in dentistry as a vasoconstrictor component in local anesthetic solutions for dental procedures such as extractions, root canals, and surgical interventions. Historically used to reduce bleeding and enhance the duration and effectiveness of local anesthesia.
Acts primarily as an alpha-1 adrenergic receptor agonist, causing vasoconstriction of local blood vessels. This reduces blood flow to the treatment area, decreases systemic absorption of the co-administered anesthetic, and prolongs local anesthetic duration.
Should be used with caution in patients with cardiovascular disease, hypertension, thyroid disease, or diabetes. Contraindicated in patients using non-selective beta-blockers or MAO inhibitors. May cause transient hypertension, tachycardia, or arrhythmias. Use during pregnancy requires careful risk-benefit assessment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy