Aminolevulinic Acid
Levulan (aminolevulinic acid) is a topical photosensitizing agent used in photodynamic therapy to treat certain skin conditions, particularly actinic keratosis. The medication is applied to affected skin areas and then activated by a specific wavelength of light, causing a photochemical reaction that destroys targeted cells. This treatment is typically administered by healthcare professionals in clinical settings.
Levulan is a topical photosensitizing agent used with light therapy to treat precancerous skin lesions like actinic keratosis.
Key facts at a glance
- RxNorm
- 469967
- Generic
- Levulan
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Levulan is primarily used to treat actinic keratosis (AK), which are rough, scaly patches on the skin caused by long-term sun exposure. It may also be used for other conditions as determined by a healthcare provider, and is generally prescribed for adults with compromised immune systems or those with multiple or extensive lesions.
Levulan is a prodrug that is metabolized in cells to form protoporphyrin IX (PpIX), a photosensitive compound. When the treated area is exposed to blue light at a specific wavelength, PpIX absorbs the light energy and produces a photochemical reaction that generates reactive oxygen species. This reaction selectively destroys the cells that have accumulated PpIX, including abnormal keratinocytes.
Levulan is for topical use only on the skin and should be applied by a healthcare professional. After application, patients must avoid exposure to sunlight, bright indoor lights, and even car headlights for at least 24-48 hours as the medication causes significant photosensitivity. Common side effects include redness, stinging, swelling, and crusting at the application site. The treatment area may appear worse before improving. Patients should discuss all current medications and medical history with their provider before treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy