Fosamprenavir
Lexiva (fosamprenavir) is an antiretroviral medication classified as a protease inhibitor, used in combination with other HIV medications to manage HIV-1 infection. It works by inhibiting the HIV protease enzyme, which is essential for the virus to replicate and produce infectious particles.
Lexiva is an HIV protease inhibitor used alongside other antiretrovirals to suppress HIV viral load and slow disease progression.
Key facts at a glance
- RxNorm
- 402108
- Generic
- Lexiva
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lexiva is indicated for the treatment of HIV-1 infection in adults and children. It is always used as part of combination antiretroviral therapy (ART), meaning it must be taken with at least one other HIV medication to be effective.
Lexiva is a prodrug that converts to amprenavir in the body. Amprenavir inhibits HIV protease, an enzyme necessary for cleaving viral polyproteins into functional components. By blocking this enzyme, the medication prevents the production of mature, infectious viral particles.
Lexiva should not be used as monotherapy due to rapid resistance development. It has numerous drug interactions, particularly with medications metabolized by CYP450 enzymes. Common side effects include rash, nausea, diarrhea, and vomiting. Patients with sulfa allergies may be at increased risk for rash. Dosage adjustments are required for patients with hepatic impairment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy