Linaclotide
Linaclotide is a medication that treats constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation by acting on guanylate cyclase-C receptors.
A locally-acting gut medication that relieves constipation and abdominal discomfort in IBS-C and chronic constipation by activating GC-C receptors.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- A06AX04
- RxNorm
- 1307404
- Generic
- Linaclotide
- Class
- atc-a06
- Brands
- Linzess
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.
Acts as a GC-C agonist, binding to receptors on the intestinal epithelial surface and increasing intracellular cGMP, which promotes fluid secretion, accelerates gut transit, and reduces visceral hypersensitivity.
Take on an empty stomach at least 30 minutes before the first meal. Common side effects include diarrhea (which may be severe), abdominal pain, and flatulence. Contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Not recommended for patients under 18 years of age.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy