Linerixibat
Linerixibat is used to treat cholestatic pruritus in PBC patients by inhibiting the ileal bile acid transporter.
Linerixibat is an IBAT inhibitor used to treat itching in PBC patients by increasing bile acid elimination through feces.
Key facts at a glance
- ATC
- A05AX08
- RxNorm
- 2665338
- Generic
- Linerixibat
- Class
- atc-a05
- Brands
- Lynavoy
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Linerixibat is indicated for the treatment of cholestatic pruritus (itching) in adult patients with Primary Biliary Cholangitis (PBC), a chronic liver disease characterized by progressive destruction of bile ducts.
Linerixibat is a reversible inhibitor of the ileal bile acid transporter (IBAT). By blocking this transporter in the terminal ileum, it prevents the reabsorption of bile acids back into the bloodstream, leading to increased fecal excretion of bile acids and reduced serum bile acid levels.
Linerixibat is an oral medication. Common adverse effects may include diarrhea, abdominal pain, and changes in bowel habits due to increased bile acid delivery to the colon. Patients should be monitored for liver function and gastrointestinal symptoms. Efficacy and safety in pediatric populations have not been established.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy