Linaclotide
Linzess is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults. It works by increasing fluid secretion in the intestines and accelerating bowel movements.
Linzess is a once-daily capsule used to treat IBS-C and chronic constipation by increasing intestinal fluid secretion.
Key facts at a glance
- RxNorm
- 1307410
- Generic
- Linzess
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Linzess is FDA-approved for treating irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults. It helps relieve abdominal pain, bloating, and infrequent bowel movements associated with these conditions.
Linzess contains linaclotide, a guanylate cyclase-C (GC-C) agonist. It binds to receptors in the intestine, increasing the secretion of fluid into the bowel and accelerating transit time, which softens stool and promotes bowel movements.
Take Linzess at least 30 minutes before the first meal of the day on an empty stomach. Common side effects include diarrhea, abdominal pain, and gas. It is contraindicated in pediatric patients and should not be used in patients with known or suspected mechanical gastrointestinal obstruction. Do not use if you are allergic to linaclotide or any of its ingredients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy