Baclofen
Lioresal (baclofen) is a muscle relaxant medication that acts on the central nervous system to reduce muscle spasticity and associated pain. It is primarily prescribed for conditions causing involuntary muscle stiffness, such as multiple sclerosis, spinal cord injuries, and certain neurological disorders affecting muscle control.
Lioresal is a prescription muscle relaxant used to treat muscle spasticity from neurological conditions.
Key facts at a glance
- RxNorm
- 202996
- Generic
- Lioresal
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lioresal is used to treat muscle spasticity associated with multiple sclerosis, spinal cord injuries or diseases, and cerebral palsy. It helps reduce muscle stiffness, pain, and involuntary muscle contractions that can interfere with movement, sleep, and daily activities.
Lioresal contains baclofen, which acts as a GABA-B receptor agonist in the spinal cord. It inhibits the release of excitatory neurotransmitters and reduces the signals that cause excessive muscle contractions, thereby decreasing spasticity and muscle stiffness.
Lioresal may cause drowsiness, dizziness, and weakness. It should not be stopped abruptly, as sudden discontinuation can cause seizures and other withdrawal symptoms. Alcohol and other CNS depressants may enhance these effects. Patients should follow their prescribing physician's dosage instructions carefully and report any persistent side effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy