Lithium Citrate
Lithostat (acetohydroxamic acid) is a urinary anti-infective agent used to treat chronic or recurrent urinary tract infections caused by urease-producing bacteria such as Proteus, Klebsiella, and Pseudomonas species. It works by inhibiting the enzyme urease, which reduces ammonia levels in the urine, creating an environment less favorable for bacterial growth and struvite stone formation. This medication is typically used alongside antibiotics and is particularly beneficial for patients with complicated UTIs or those prone to developing infection-related kidney stones.
Lithostat is a urinary anti-infective medication that inhibits urease to treat recurrent UTIs and help prevent struvite kidney stones.
Key facts at a glance
- RxNorm
- 52110
- Generic
- Lithostat
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lithostat is used to treat chronic or recurrent urinary tract infections caused by urease-producing bacteria. It is also used to help prevent the formation of struvite (infection) kidney stones, which develop in the alkaline urinary environment created by these bacteria.
Lithostat inhibits the enzyme urease, which bacteria use to break down urea into ammonia. By reducing ammonia production in the urinary tract, the medication lowers urinary pH and creates conditions less hospitable to urease-producing pathogens and struvite crystallization.
Lithostat is typically used in combination with antibiotics rather than as monotherapy. It is contraindicated during pregnancy due to potential fetal harm. Common side effects may include gastrointestinal disturbances, headache, or skin rash. Regular monitoring of hemoglobin levels is recommended as mild anemia may occur. Patients should take the medication consistently as prescribed for optimal effectiveness.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy