Lixisenatide
Lixisenatide is a GLP-1 receptor agonist used with insulin glargine to improve glycemic control in adults with type 2 diabetes by enhancing glucose-dependent insulin secretion.
A combination therapy of GLP-1 agonist and basal insulin for type 2 diabetes when single agents are insufficient.
Key facts at a glance
- ATC
- A10BJ03
- RxNorm
- 1440051
- Generic
- Lixisenatide
- Class
- atc-a10
- Brands
- Soliqua
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Improvement of glycemic control in adults with type 2 diabetes mellitus inadequately controlled on basal insulin alone, or on lixisenatide alone, or on oral antidiabetic agents (metformin, sulfonylureas, or SGLT2 inhibitors) in combination with basal insulin.
As a GLP-1 receptor agonist, lixisenatide stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying to reduce postprandial glucose spikes, and promotes satiety. When combined with insulin glargine, it provides complementary glycemic control through both basal insulin coverage and GLP-1 receptor activation.
Administered as a once-daily subcutaneous injection within 1 hour before the first meal. Not recommended for use with insulin secretagogues (sulfonylureas) due to hypoglycemia risk without dose adjustment. Associated with risk of gastrointestinal adverse effects (nausea, vomiting, diarrhea). Contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Not indicated for type 1 diabetes or diabetic ketoacidosis.
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy