Lofepramine
Lofepramine is a tricyclic antidepressant (TCA) that was commonly used to treat depression and anxiety-related conditions. It works by inhibiting the reuptake of norepinephrine and serotonin in the brain, helping to restore chemical balance and improve mood. While effective, it has largely been replaced by newer antidepressants with fewer side effects.
Lofepramine is an older tricyclic antidepressant for treating depression that increases norepinephrine and serotonin levels in the brain.
Key facts at a glance
- ATC
- N06AA07
- RxNorm
- 6465
- Generic
- Lofepramine
- Class
- atc-n06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for major depressive disorder and depression associated with anxiety. May also be used for other mood disorders as determined by a healthcare provider.
Functions as a prodrug converted to desipramine in the body. Inhibits reuptake of norepinephrine and serotonin at nerve synapses, increasing their availability for mood regulation.
Requires dosage titration and regular monitoring. Like other TCAs, may cause anticholinergic effects (dry mouth, constipation, urinary retention), sedation, weight changes, and cardiac effects. Caution needed in patients with cardiovascular disease, glaucoma, or urinary retention. Overdose can be life-threatening. May interact with MAOIs, other serotonergic agents, and alcohol.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy