Lofexidine
Lofexidine is a centrally acting alpha-2 adrenergic agonist used to reduce opioid withdrawal symptoms. It works by binding to alpha-2 receptors on adrenergic neurons, which decreases norepinephrine release and reduces sympathetic nervous system activity. This medication is specifically approved for the management of opioid withdrawal symptoms in adults.
Lofexidine is an alpha-2 agonist medication used to alleviate symptoms of opioid withdrawal.
Key facts at a glance
- ATC
- N07BC04
- RxNorm
- 28863
- Generic
- Lofexidine
- Class
- atc-n07
- Brands
- Lucemyra
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lofexidine is FDA-approved for mitigating opioid withdrawal symptoms in adults undergoing abrupt discontinuation of opioids. It helps manage autonomic symptoms such as anxiety, agitation, sweating, rhinorrhea (runny nose), yawning, piloerection, myalgia, nausea, vomiting, and diarrhea associated with opioid withdrawal.
As a central alpha-2 adrenergic agonist, lofexidine binds to alpha-2 receptors presynaptically on adrenergic neurons in the central nervous system. This activation inhibits norepinephrine release, thereby reducing sympathetic tone and the hyperactive autonomic response characteristic of opioid withdrawal.
Lofexidine may cause hypotension, bradycardia, and QT prolongation; patients should be monitored for cardiovascular effects. It is typically used as part of a comprehensive treatment program that includes psychosocial support. The medication is usually initiated at the onset of opioid withdrawal symptoms and is not a treatment for opioid use disorder itself.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy