Sodium Zirconium Cyclosilicate
Lokelma (sodium zirconium cyclosilicate) is a potassium binder used to treat hyperkalemia, a condition characterized by dangerously high potassium levels in the blood. It works by binding to potassium in the gastrointestinal tract and removing it from the body through stool. This medication is typically prescribed for patients with chronic kidney disease, heart failure, or those on certain blood pressure medications that can increase potassium levels.
Lokelma is a potassium-lowering medication used to treat elevated blood potassium levels in patients with kidney disease or heart failure.
Key facts at a glance
- RxNorm
- 2047634
- Generic
- Lokelma
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lokelma is indicated for the treatment of hyperkalemia in adult patients. It is commonly used in patients with chronic kidney disease (CKD), heart failure, or diabetes, as well as those taking medications such as renin-angiotensin-aldosterone system (RAAS) inhibitors that can raise potassium levels.
Lokelma is an orally administered potassium binder. It works by exchanging potassium ions for hydrogen and sodium ions in the gastrointestinal tract, particularly in the colon. This binding process allows excess potassium to be excreted in the stool, thereby lowering blood potassium levels.
Lokelma is not indicated for emergency treatment of severe hyperkalemia. It should be taken with water and may interact with other medications, so timing separation may be needed. Common side effects may include edema and hypokalemia (low potassium). Patients should follow their healthcare provider's dosing instructions carefully and have potassium levels monitored regularly.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy