Diphenoxylate-Atropine
Lomotil is a brand-name prescription medication used to treat acute and chronic diarrhea. It contains a combination of diphenoxylate, an opioid that slows intestinal movement, and atropine, which discourages misuse. This medication is typically used when other anti-diarrheal treatments have not been effective.
Lomotil is a prescription anti-diarrheal medication that works by slowing intestinal contractions to reduce the frequency of bowel movements.
Key facts at a glance
- RxNorm
- 28874
- Generic
- Lomotil
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lomotil is prescribed for the treatment of acute and chronic diarrhea, including gastroenteritis, inflammatory bowel disease flare-ups, and traveler's diarrhea. It is generally used when milder anti-diarrheal medications have failed to provide adequate relief.
The diphenoxylate component binds to opioid receptors in the gastrointestinal tract, reducing intestinal motility and allowing more time for water and electrolytes to be absorbed. The small amount of atropine discourages misuse by causing unpleasant effects if taken in excessive doses.
Lomotil is a controlled substance due to its opioid component and carries a risk of dependence with prolonged use. It should not be used by patients with bacterial infections (such as dysentery), certain liver conditions, or those who are pregnant unless specifically directed by a healthcare provider. Common side effects include drowsiness, dizziness, dry mouth, and constipation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy