Lonapegsomatropin
Lonapegsomatropin is a long-acting, pegylated form of somatropin (human growth hormone) designed for once-weekly subcutaneous administration in children with growth hormone deficiency. This modified growth hormone provides sustained hormone levels throughout the week, offering an alternative to daily growth hormone injections while maintaining similar efficacy in promoting growth and metabolic functions.
A once-weekly pegylated growth hormone therapy for children with growth hormone deficiency, offering fewer injections than traditional daily treatments.
Key facts at a glance
- ATC
- H01AC09
- RxNorm
- 2569562
- Generic
- Lonapegsomatropin
- Class
- atc-h01
- Brands
- Skytrofa
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of growth hormone deficiency in children who have inadequate growth. It is specifically indicated for pediatric patients who have growth failure due to insufficient endogenous growth hormone secretion.
Lonapegsomatropin is a pegylated form of somatropin that binds to growth hormone receptors on target cells, triggering intracellular signal transduction pathways. The pegylation process extends the half-life of the hormone, allowing for once-weekly dosing while maintaining therapeutic activity throughout the dosing interval.
Administered as a subcutaneous injection once weekly. Should be used under the supervision of a physician experienced in managing pediatric growth disorders. Common side effects may include injection site reactions, headaches, and transient changes in metabolic markers. Regular monitoring of growth response, IGF-1 levels, and safety parameters is recommended during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy