Metoprolol-Hydrochlorothiazide
Lopressor HCT is a combination medication that contains metoprolol, a beta-blocker, and hydrochlorothiazide, a diuretic. It is primarily prescribed to treat high blood pressure (hypertension). The two active ingredients work together: metoprolol reduces heart rate and the force of heart contractions, while the diuretic helps remove excess fluid from the body.
A combination blood pressure medication pairing a beta-blocker with a diuretic to manage hypertension.
Key facts at a glance
- RxNorm
- 218072
- Generic
- Lopressor Hct
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hypertension (high blood pressure) in patients who require combination therapy when single-agent therapy is insufficient.
Metoprolol blocks beta-1 receptors in the heart, reducing heart rate and cardiac output. Hydrochlorothiazide is a thiazide diuretic that promotes fluid loss through increased urination, reducing blood volume and further lowering blood pressure.
Do not stop taking this medication abruptly, as sudden discontinuation may cause rebound hypertension or worsen chest pain. Common side effects include dizziness, fatigue, and increased urination. Regular blood pressure monitoring and laboratory tests (electrolytes, kidney function) are recommended during treatment. May not be suitable for patients with certain heart conditions, severe kidney disease, or sulfa drug allergies.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy