Lorlatinib
Lorlatinib is a targeted cancer therapy known as a kinase inhibitor, designed to block specific proteins that drive cancer cell growth. It is primarily used to treat adults with advanced non-small cell lung cancer (NSCLC) that tests positive for ALK gene rearrangements, including tumors that have become resistant to earlier ALK inhibitor therapies.
Lorlatinib is a targeted kinase inhibitor used to treat advanced ALK-positive non-small cell lung cancer that has progressed after other treatments.
Key facts at a glance
- ATC
- L01ED05
- RxNorm
- 2103164
- Generic
- Lorlatinib
- Class
- atc-l01
- Brands
- Lorbrena
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with ALK-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to previous ALK inhibitor therapy such as crizotinib, alectinib, or brigatinib.
Lorlatinib inhibits anaplastic lymphoma kinase (ALK) and ROS1 receptors, blocking signaling pathways that cancer cells use to grow, divide, and spread. It also targets other kinases including TRK and FAK, and remains active against several ALK resistance mutations.
Common side effects include edema, weight gain, neuropathy, and cognitive effects. Requires regular monitoring of cholesterol, triglycerides, and liver function. May cause serious CNS side effects and should be used with caution in patients with cardiovascular disease. Must be taken consistently with or without food.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy