Amlodipine-Benazepril
Lotrel is a brand-name combination medication that contains two active ingredients—amlodipine, a calcium channel blocker, and benazepril, an ACE inhibitor—working together to lower blood pressure. It is prescribed for the treatment of hypertension (high blood pressure) when single-agent therapy is insufficient. The two-component approach targets blood pressure regulation through different mechanisms for enhanced effectiveness.
Lotrel is a combination blood pressure medication used when single antihypertensive agents are not enough to control hypertension.
Key facts at a glance
- RxNorm
- 218090
- Generic
- Lotrel
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lotrel is indicated for the treatment of hypertension (high blood pressure) in patients who require combination therapy to achieve adequate blood pressure control.
Lotrel combines two complementary mechanisms: amlodipine is a calcium channel blocker that relaxes blood vessels by preventing calcium from entering muscle cells, while benazepril is an ACE inhibitor that blocks an enzyme involved in tightening blood vessels. Together, they lower blood pressure more effectively than either component alone.
Lotrel should not be used during pregnancy as it can cause fetal harm. Common side effects may include swelling (edema), dizziness, headache, and cough. Patients with a history of angioedema or those taking aliskiren should use this medication with caution. Regular monitoring of blood pressure, kidney function, and potassium levels is recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy