Lubiprostone
Lubiprostone is a chloride channel activator used to treat chronic constipation, IBS-C, and opioid-induced constipation by acting locally in the intestines.
Lubiprostone is a laxative that increases intestinal fluid secretion to relieve chronic constipation and IBS-C.
Key facts at a glance
- ATC
- A06AX03
- RxNorm
- 623033
- Generic
- Lubiprostone
- Class
- atc-a06
- Brands
- Amitiza
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Chronic idiopathic constipation, irritable bowel syndrome with constipation (IBS-C), and opioid-induced constipation in adults with chronic non-cancer pain.
Lubiprostone locally activates ClC-2 chloride channels in the intestines, enhancing chloride-rich fluid secretion into the GI tract. This increases intestinal fluid volume, softening stools and promoting improved bowel motility without systemic absorption or effects on blood electrolyte concentrations.
May cause nausea, diarrhea, and abdominal pain. Should be taken with food and water. Not recommended during pregnancy. Patients should discontinue if severe diarrhea occurs. May interact with other medications affecting intestinal motility.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy