Sotorasib
Lumakras (sotorasib) is a targeted therapy medication used to treat adults with non-small cell lung cancer (NSCLC) that has spread and contains a specific genetic mutation called KRAS G12C, in patients who have received at least one prior systemic therapy. It works by specifically targeting and inhibiting the mutated KRAS protein that contributes to cancer cell growth and survival.
Lumakras is a KRAS G12C inhibitor used to treat certain patients with advanced non-small cell lung cancer harboring the KRAS G12C mutation.
Key facts at a glance
- RxNorm
- 2550720
- Generic
- Lumakras
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) who have received at least one prior systemic therapy. The presence of the KRAS G12C mutation must be confirmed by an FDA-approved test before use.
Lumakras is a KRAS G12C inhibitor that irreversibly binds to the mutated KRAS G12C protein, locking it in an inactive state and preventing it from transmitting signals that promote cancer cell growth, proliferation, and survival.
This is a targeted therapy that requires genetic testing to confirm the KRAS G12C mutation before treatment. Common side effects may include gastrointestinal symptoms and fatigue. Patients should be monitored for liver function changes and other adverse reactions. Treatment should be overseen by an oncologist experienced in the use of targeted cancer therapies.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy