Lumateperone
Lumateperone is an atypical antipsychotic medication used to treat schizophrenia in adults and depressive episodes associated with bipolar depression. It can be used as monotherapy or as an adjunctive treatment with mood stabilizers (lithium or valproate) or antidepressants. The medication works by modulating dopamine, serotonin, and glutamate neurotransmitter systems in the brain.
Lumateperone is an antipsychotic used to treat schizophrenia and bipolar depression by modulating multiple brain neurotransmitters.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05AD10
- RxNorm
- 2275602
- Generic
- Lumateperone
- Class
- atc-n05
- Brands
- Caplyta
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of schizophrenia in adults; treatment of depressive episodes associated with bipolar I or II disorder as monotherapy or as adjunctive therapy with lithium or valproate; and as adjunctive therapy with antidepressants.
Lumateperone is a dopamine D2 receptor antagonist and serotonin 5-HT2A receptor antagonist. It also exhibits activity at 5-HT1A receptors, D1 receptors, and acts as a serotonin reuptake inhibitor, providing a multimodal mechanism that differentiates it from other antipsychotics.
Common side effects may include somnolence, dry mouth, and dizziness. It is not approved for use in elderly patients with dementia-related psychosis due to increased mortality risk. Patients should be monitored for metabolic changes, weight gain, and movement disorders. Avoid use during pregnancy unless benefits outweigh risks.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy