Lurbinectedin
Lurbinectedin is an alkylating agent used to treat adults with metastatic small cell lung cancer (SCLC) that has progressed after prior platinum-based chemotherapy. It works by binding to the minor groove of DNA, forming adducts that cause DNA bending and interfere with cancer cell replication and survival.
Lurbinectedin is an alkylating chemotherapy agent used for metastatic small cell lung cancer after prior treatment failure.
Key facts at a glance
- ATC
- L01XX69
- RxNorm
- 2374729
- Generic
- Lurbinectedin
- Class
- atc-l01
- Brands
- Zepzelca
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lurbinectedin is indicated for the treatment of adult patients with metastatic small cell lung cancer (SCLC) who have disease progression following platinum-based chemotherapy.
As an alkylating agent, lurbinectedin binds to guanine residues in the minor groove of DNA, forming adducts that bend the DNA helix toward the major groove. This DNA damage disrupts transcription and replication processes, leading to cancer cell death.
Lurbinectedin is administered by intravenous infusion. Common side effects may include fatigue, nausea, and myelosuppression. It should be used with caution in patients with hepatic impairment. Treatment should be supervised by oncologists experienced in chemotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy