Luspatercept-Aamt
Luspatercept-Aamt is a modified activin receptor protein used to treat anemia in patients with beta-thalassemia who require regular red blood cell transfusions, as well as anemia associated with myelofibrosis. It works by binding to TGF-beta superfamily ligands to promote red blood cell maturation and production.
A protein-based therapy for anemia associated with beta-thalassemia and myelofibrosis that helps increase red blood cell production.
Key facts at a glance
- RxNorm
- 2262543
- Generic
- Luspatercept-Aamt
- Class
- pin-variant
- Brands
- Reblozyl
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of anemia in beta-thalassemia patients requiring regular red blood cell transfusions, and treatment of anemia in myelofibrosis patients.
A modified activin receptor type IIB fusion protein that binds TGF-beta superfamily ligands, inhibiting Smad2/3 signaling that normally suppresses erythropoiesis, thereby promoting red blood cell maturation.
Administered as subcutaneous injection. Monitor blood pressure and hemoglobin levels during treatment. May cause hypertension, fatigue, or musculoskeletal pain. Not indicated as emergency treatment for anemia requiring immediate transfusion.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy