Lusutrombopag
Lusutrombopag is an oral thrombopoietin receptor agonist used to treat thrombocytopenia (low platelet count) in adults with chronic liver disease who are scheduled to undergo invasive procedures. By stimulating platelet production through activation of TPO receptors on megakaryocyte progenitor cells, it helps reduce the risk of bleeding complications associated with low platelet counts.
An oral medication that stimulates platelet production in patients with chronic liver disease-related thrombocytopenia.
Key facts at a glance
- ATC
- B02BX07
- RxNorm
- 2054984
- Generic
- Lusutrombopag
- Class
- atc-b02
- Brands
- Mulpleta
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Lusutrombopag is indicated for the treatment of thrombocytopenia in adult patients with chronic liver disease who are at increased risk of bleeding due to low platelet counts and are scheduled to undergo invasive procedures.
Lusutrombopag is a small molecule TPO receptor agonist that binds to the transmembrane domain of thrombopoietin receptors on megakaryocyte progenitor cells, stimulating their proliferation and differentiation to increase platelet production.
Lusutrombopag is taken orally once daily for a limited duration before a planned procedure. Treatment should be supervised by a physician experienced in managing thrombocytopenia. Patients should be monitored for platelet counts and potential thrombotic risk. The medication is contraindicated in patients with known hypersensitivity to the drug or its components.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy