Lifitegrast
Lyfgenia (lovotibeglogene autotemcel) is an autologous gene therapy approved for the treatment of sickle cell disease in patients 12 years and older. It works by genetically modifying the patient's own blood stem cells to produce a modified form of hemoglobin that reduces red blood cell sickling. This one-time therapy is administered as a single treatment and requires chemotherapy prior to infusion to prepare the body.
Lyfgenia is a gene therapy for sickle cell disease that modifies a patient's own stem cells to reduce red blood cell sickling.
Key facts at a glance
- RxNorm
- 2672693
- Generic
- Lyfgenia
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Treatment of sickle cell disease in patients 12 years of age and older with a history of vaso-occlusive events.
Autologous gene therapy that adds a functional copy of the beta-globin gene to the patient's own hematopoietic stem cells, which then produce a modified hemoglobin (HbA^T87Q) that decreases sickling of red blood cells.
This is a one-time, single-course treatment. Requires myeloablative chemotherapy prior to infusion. Contains a boxed warning for hematologic malignancy risk. Patients should be monitored long-term. Not indicated for patients with history of severe allergic reactions to dimethyl sulfoxide or gentamicin.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy