Mafenide
Mafenide is a topical sulfonamide antibiotic used to prevent and treat bacterial infections in burn wounds. It is applied directly to the skin and is particularly effective against a broad spectrum of gram-negative and gram-positive bacteria.
Topical antibiotic for preventing and treating infections in burn wounds.
Key facts at a glance
- ATC
- D06BA03
- RxNorm
- 6572
- Generic
- Mafenide
- Class
- atc-d06
- Brands
- Sulfamylon
- Availability
- rx
- Lactation
- unknown
- Routes
- topical
- Forms
- solution, cream
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention and treatment of bacterial infections in second- and third-degree burn wounds. Often used when patients have hypersensitivity reactions to other topical antibiotics.
Mafenide acts as a carbonic anhydrase inhibitor and exhibits antibacterial activity by penetrating burn eschar and tissues to suppress bacterial growth.
May cause metabolic acidosis due to carbonic anhydrase inhibition, particularly in patients with large burn areas. Can cause pain or burning sensation upon application. Contraindicated in patients with sulfonamide sensitivity. Use with caution in patients with renal impairment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy