Malathion
Malathion is a topical pediculicide used to treat infestations of head lice and pubic lice (pthiriasis). It is an organophosphate insecticide that works by disrupting the nervous system of insects, leading to their death. This medication is typically applied as a liquid lotion to affected areas and is available by prescription or over-the-counter depending on the formulation and region.
Malathion is a topical lice treatment that kills head and pubic lice by disrupting their nervous system.
Key facts at a glance
- ATC
- P03AX03
- RxNorm
- 6606
- Generic
- Malathion
- Class
- atc-p03
- Brands
- Ovide
- Availability
- rx
- Pregnancy
- B
- Lactation
- safe
- Routes
- topical
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Malathion is used to treat infestations by head lice (Pediculus humanus capitis) and pubic lice (Pthirus pubis), commonly known as crabs. It is applied directly to the hair and scalp for head lice or to the pubic region for pubic lice.
Malathion is an organophosphate insecticide that inhibits cholinesterase enzymes in insects. This disruption of the insect's nervous system causes paralysis and death of the lice and their eggs (nits).
Malathion is for external use only and should not be ingested. It should be kept away from open flames and heat sources as it is flammable. Avoid contact with eyes, nose, mouth, and other mucous membranes. Do not use on infants or very young children without medical supervision. Pregnant or breastfeeding individuals should consult a healthcare provider before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy