Mecasermin
Mecasermin is a recombinant form of insulin-like growth factor-1 (IGF-1) used to treat growth disorders caused by IGF-1 deficiency. It is prescribed for children with conditions such as primary IGF-1 deficiency or growth hormone insensitivity syndrome (Laron syndrome) who have low IGF-1 levels but normal or elevated growth hormone. The medication promotes linear growth by directly providing the hormone needed for normal skeletal development.
Mecasermin is a synthetic IGF-1 hormone used to treat growth failure in children with IGF-1 deficiency or growth hormone insensitivity.
Key facts at a glance
- ATC
- H01AC03
- RxNorm
- 274403
- Generic
- Mecasermin
- Class
- atc-h01
- Brands
- Increlex
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of growth failure in children with severe primary IGF-1 deficiency (primary IGFD) and growth hormone insensitivity syndrome (GHIS, also known as Laron syndrome). These are rare conditions where the body cannot produce or respond to adequate levels of IGF-1 despite normal or elevated growth hormone secretion.
Mecasermin provides exogenous IGF-1, bypassing the need for growth hormone stimulation. IGF-1 normally mediates the growth-promoting effects of growth hormone on bones and tissues. By directly supplying IGF-1, mecarsermin stimulates linear growth, skeletal maturation, and cellular proliferation in target tissues.
Administered by subcutaneous injection once or twice daily. Common side effects include hypoglycemia (must be given with food), injection site reactions, and headache. Contraindicated in patients with active or suspected neoplasia. Requires careful monitoring of blood glucose, growth response, and IGF-1 levels. Should only be prescribed by specialists experienced in managing growth disorders.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy