Mecobalamin
Mecobalamin is an active form of vitamin B12 that plays a crucial role in nerve function, red blood cell formation, and DNA synthesis. It is primarily used to treat vitamin B12 deficiency states, including pernicious anemia and peripheral neuropathy, and may support neurological health in certain conditions.
Mecobalamin is a form of vitamin B12 used to treat deficiency states and support nerve health.
Key facts at a glance
- ATC
- B03BA05
- RxNorm
- 29421
- Generic
- Mecobalamin
- Class
- atc-b03
- Brands
- Dialyvite 800, Dialyvite 800 with Zinc, Dialyvite 800 with Iron
- Availability
- rx
- Lactation
- unknown
- Routes
- oral, sublingual
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteruse only if clearly needed
use only when benefits outweigh potential risks
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimesteruse only if clearly needed
continue if already on therapy for deficiency
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse only if clearly needed
continue if already on therapy for deficiency
regular prenatal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment needed
generally considered safe during breastfeeding
infant monitoring if high doses
pediatric_age
children under 12dose based on weight
use under medical supervision for confirmed deficiency
regular blood count monitoring
Use with caution and monitor for adverse effects.
geriatric
elderlyno adjustment needed for mild cases
commonly needed due to decreased absorption in elderly
periodic B12 levels and blood count
renal_impairment
severe renal impairmentuse with caution monitor levels
monitor serum B12 and renal function
regular serum B12 and renal function tests
Use with caution and monitor for adverse effects.
hepatic_impairment
moderate to severeno adjustment needed
generally does not require dose adjustment
periodic liver function tests
Statistics and clinical data
Drug class
Mecobalamin is the active form of vitamin B12
Common uses
Therapeutic indications for Mecobalamin
Mechanism of action
Pharmacological mechanism
Commonly prescribed since
Historical prescribing information
Treatment of vitamin B12 deficiency, pernicious anemia, megaloblastic anemia, peripheral neuropathy, and neurological disorders associated with B12 insufficiency. May be used for diabetic neuropathy and other nerve-related conditions.
As an active coenzyme form of vitamin B12, mecobalamin supports methylation processes, helps maintain the myelin sheath surrounding nerves, and aids in the production of red blood cells and DNA synthesis.
Generally well-tolerated with minimal side effects. Should be used under medical supervision to confirm B12 deficiency before treatment. May interact with certain medications including metformin and proton pump inhibitors. Not a substitute for addressing underlying causes of deficiency.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy