Mefloquine HydrochlorideMedically reviewed by WellAlly Editorial Team·Last reviewed August 28, 2026·[Editorial policy](https://wellally.tech/editorial-policy)
## Key facts at a glance
RxNorm82130GenericMefloquine HydrochlorideClasspin-variantBrands—AvailabilityrxLactationunknownRoutes—Forms—RegionsUS, EU, CN, JPMonitoring—

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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.


Prevention and treatment of malaria caused by susceptible Plasmodium species, including P. falciparum. Commonly used for chemoprophylaxis in travelers to malaria-endemic regions and for acute uncomplicated malaria treatment when other agents are not suitable.


Mefloquine is a quinoline derivative that accumulates in infected red blood cells and interacts with the parasite's hemoglobin digestion pathway, ultimately causing parasite death through disruption of protein synthesis and cellular function.


Carries boxed warnings for serious neuropsychiatric reactions including anxiety, depression, and hallucinations. Not recommended for patients with history of psychiatric disorders or seizure disorders. Resistance has been reported in some regions. Should be started 1-3 weeks before travel and continued after leaving endemic area. Contraindicated with quinine, quinidine, and halofantrine.


## Official drug label

- DailyMed (FDA) — full prescribing information
- MedlinePlus — consumer drug information


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Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy