Megestrol
Megestrol is a synthetic progestogen medication primarily used in the treatment of advanced breast and endometrial cancers, where it acts as hormonal therapy by binding to progesterone receptors and inhibiting tumor growth. It is also prescribed to stimulate appetite and promote weight gain in patients experiencing severe wasting associated with AIDS or cancer. Available in oral tablet and suspension formulations, this medication requires a prescription and should be used under medical supervision.
Megestrol is a hormonal therapy used for certain cancers and appetite stimulation in wasting syndromes.
Key facts at a glance
- ATC
- G03AC05
- RxNorm
- 6703
- Generic
- Megestrol
- Class
- atc-g03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Megestrol is indicated for the palliative treatment of advanced breast cancer and endometrial cancer in women, as well as for the treatment of anorexia, cachexia, or unexplained significant weight loss in patients with AIDS or cancer to improve appetite and nutritional intake.
Megestrol acetate is a synthetic progestogen that binds to progesterone receptors in target tissues. Its anticancer effects are achieved through inhibition of pituitary LH secretion and direct antiproliferative effects on hormone-sensitive tumors. For appetite stimulation, it acts on hypothalamic receptors involved in hunger regulation.
Common side effects may include weight gain, nausea, menstrual irregularities, and fluid retention. Megestrol should not be used during pregnancy due to potential harm to the fetus. Patients with a history of thromboembolic disorders should use caution. It may interact with other medications; always inform your healthcare provider of all current medications and medical conditions before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy