Trametinib
Mekinist (trametinib) is a prescription brand-name medication classified as a MEK inhibitor, a type of targeted cancer therapy. It is primarily used to treat certain types of melanoma and non-small cell lung cancer that have specific genetic mutations. Mekinist works by blocking MEK proteins that promote cancer cell growth and division, and it may be used alone or in combination with other cancer medications.
Mekinist is a targeted cancer therapy (MEK inhibitor) used to treat specific melanomas and lung cancers with BRAF mutations.
Key facts at a glance
- RxNorm
- 1425105
- Generic
- Mekinist
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mekinist is FDA-approved for treating unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and in combination with dabrafenib for BRAF V600E-mutant non-small cell lung cancer. It may also be used for other cancers as determined by an oncologist.
Mekinist inhibits MEK1 and MEK2 proteins, which are key components of the MAPK signaling pathway that controls cell growth, division, and survival. By blocking this pathway, it slows or stops the growth of cancer cells that depend on this signaling.
Mekinist should only be used in patients whose tumors have confirmed BRAF mutations. Common side effects may include skin rash, fever, fatigue, and swelling. It can cause serious side effects including heart problems, lung issues, and visual disturbances. Regular monitoring and blood tests are required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy