Binimetinib
Mektovi (binimetinib) is a prescription MEK inhibitor used in combination with other medications to treat adults with BRAF V600E or V600K mutation-positive unresectable or metastatic melanoma. It targets the MAPK signaling pathway to slow cancer cell growth and proliferation. This medication is typically used when the melanoma cannot be removed by surgery or has spread to other parts of the body.
Mektovi is a targeted therapy MEK inhibitor used with other drugs to treat advanced melanoma with specific BRAF mutations.
Key facts at a glance
- RxNorm
- 2049128
- Generic
- Mektovi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mektovi is indicated for the treatment of patients with BRAF V600E or V600K mutation-positive unresectable or metastatic melanoma. It is used in combination with encorafenib (Braftovi) and is not recommended for use as a single agent.
Mektovi is a mitogen-activated protein kinase kinase (MEK) inhibitor. It works by blocking the activity of MEK proteins in the MAPK signaling pathway, which is involved in cell growth and division. By inhibiting this pathway, it helps slow the growth and spread of cancer cells with BRAF mutations.
Mektovi should only be used in patients whose tumors have confirmed BRAF V600E or V600K mutations. Common side effects may include fatigue, nausea, diarrhea, and skin-related reactions. Patients should be monitored for potential serious adverse effects including cardiac events, liver problems, and retinal issues. Regular monitoring and blood tests are typically required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy