Menatetrenone
Menatetrenone is a synthetic form of vitamin K2 (menaquinone-4) used primarily for the treatment of osteoporosis. It works by promoting bone formation and reducing bone resorption, helping to improve bone mineral density. This medication is commonly prescribed in Japan and several Asian countries for patients at risk of fractures due to weakened bones.
Menatetrenone is a vitamin K2-based medication used to treat osteoporosis by improving bone strength and reducing fracture risk.
Key facts at a glance
- ATC
- M05BX08
- RxNorm
- 29495
- Generic
- Menatetrenone
- Class
- atc-m05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for osteoporosis, particularly in patients with decreased bone mass or those at risk of fractures. It may also be used for osteopenia and other conditions involving impaired bone metabolism.
Menatetrenone activates osteocalcin, a protein essential for binding calcium to the bone matrix. This promotes bone mineralization and inhibits osteoclast activity, leading to reduced bone resorption and improved bone strength.
Should be taken with food for better absorption. Patients on anticoagulant therapy (warfarin) should consult their doctor as vitamin K can interfere with blood thinner effectiveness. Common side effects may include gastrointestinal discomfort. Regular monitoring of bone density may be recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy