Estradiol
Menest is a brand-name estrogen replacement therapy containing esterified estrogens, used to treat symptoms of menopause such as hot flashes and vaginal dryness, and to prevent postmenopausal osteoporosis. It is prescribed for women experiencing estrogen deficiency due to menopause, surgical removal of ovaries, or primary ovarian insufficiency.
Menest is an estrogen replacement medication for women with low estrogen levels to relieve menopausal symptoms and prevent bone loss.
Key facts at a glance
- RxNorm
- 218309
- Generic
- Menest
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Menest is used to treat moderate to severe vasomotor symptoms of menopause, vaginal atrophy, and to prevent postmenopausal osteoporosis. It may also be prescribed for estrogen deficiency due to hypogonadism, castration, or primary ovarian insufficiency.
Menest contains esterified estrogens (sodium estrone sulfate and sodium equilin sulfate) that bind to estrogen receptors in various tissues throughout the body, supplementing declining natural estrogen levels and alleviating menopausal symptoms while helping maintain bone density.
Should not be used during pregnancy. Associated with increased risks of endometrial cancer (when used without progestin), stroke, deep vein thrombosis, and breast cancer. Use lowest effective dose for shortest duration consistent with treatment goals. Contraindicated in patients with estrogen-dependent tumors, undiagnosed genital bleeding, or active thrombophlebitis.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy