Mesna
Mesna is a uroprotective agent used as an adjuvant therapy with ifosfamide and certain doses of cyclophosphamide chemotherapy. It works by chemically neutralizing toxic metabolites excreted in urine, preventing damage to the bladder lining and hemorrhagic cystitis.
Mesna protects the bladder from chemotherapy-induced toxicity by inactivating harmful urinary metabolites.
Key facts at a glance
- ATC
- R05CB05
- RxNorm
- 44
- Generic
- Mesna
- Class
- atc-r05
- Brands
- Mesnex
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of hemorrhagic cystitis and bladder damage associated with ifosfamide and high-dose cyclophosphamide in adults and children undergoing chemotherapy.
Mesna contains a sulfhydryl group that chemically binds to and neutralizes urotoxic ifosfamide metabolites (acrolein and 4-hydroxy-ifosfamide), forming non-toxic compounds that are safely excreted in urine.
Typically administered intravenously or orally, usually in divided doses timed with chemotherapy. Must be given with each dose and for a period after chemotherapy. Adequate hydration is important. May cause false-positive urine ketone tests.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy