Mesna
Mesnex is a chemoprotective agent used to prevent hemorrhagic cystitis (bladder damage and bleeding) caused by certain chemotherapy drugs. It works by neutralizing toxic metabolites in the urine that would otherwise damage the bladder lining. The medication is typically given alongside ifosfamide or cyclophosphamide chemotherapy regimens.
Mesnex protects the bladder from chemotherapy-induced damage by neutralizing harmful urinary metabolites.
Key facts at a glance
- RxNorm
- 218330
- Generic
- Mesnex
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of hemorrhagic cystitis associated with ifosfamide or cyclophosphamide chemotherapy. It may also be used in other situations where bladder protection from chemical irritants is needed.
Mesna contains a thiol compound that binds to and neutralizes acrolein, a toxic metabolite produced when ifosfamide and cyclophosphamide are broken down in the body. By inactivating acrolein in the urinary tract, it prevents bladder mucosal damage and bleeding.
Administered orally or intravenously, typically at each dose of chemotherapy and several hours after. Patients should maintain adequate hydration and urinate frequently during treatment. May cause mild nausea, vomiting, or allergic reactions. Does not protect against other chemotherapy side effects and must be used alongside the full prescribed chemotherapy regimen.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy