Methoxsalen
Methoxsalen is a psoralen derivative used in combination with UVA light therapy (PUVA) to treat certain skin conditions. When activated by ultraviolet light, it forms covalent bonds with DNA in skin cells, affecting cell division and promoting repigmentation. It is primarily prescribed by dermatologists for conditions such as psoriasis, vitiligo, and other responsive skin disorders.
Methoxsalen is a photosensitizing medication used with UVA light therapy to treat skin conditions like psoriasis and vitiligo.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- D05AD02
- RxNorm
- 6854
- Generic
- Methoxsalen
- Class
- atc-d05
- Brands
- Uvadex
- Availability
- rx
- Lactation
- unknown
- Routes
- oral, topical
- Forms
- solution, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe psoriasis, vitiligo, and other skin conditions responsive to photochemotherapy; commonly used as part of PUVA (psoralen plus UVA) treatment protocols
Methoxsalen is a photosensitizing agent that, upon activation by UVA light, forms covalent bonds with DNA in skin cells, inhibiting rapid cell division and promoting repigmentation in affected areas
Requires strict sun protection during and after treatment; must be used with UVA light exposure under medical supervision; associated with increased risk of skin cancer with long-term use; contraindicated in patients with certain light-sensitive conditions or malignancies; regular eye examinations recommended due to cataract risk
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy